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Tuesday, December 24, 2013
Build a Signaling Pathway
Which of these is a logical signal transduction pathway?
An ion-channel receptor opens, allowing a steroid hormone to enter the cell; the steroid hormone then activates protein kinases that convert GTP to GDP, which binds to an intracellular enzyme that carries out a response.
A receptor tyrosine kinase activates adenylyl cyclase, which activates phospholipase C, which converts ATP into cyclic AMP, which binds to an intracellular enzyme that carries out a response.
A G-protein-linked receptor activates G protein, which activates phospholipase C, which cleaves a membrane lipid to form IP
, which binds to a calcium channel on the ER, which opens to release calcium ions into the cytoplasm, which bind to an intracellular enzyme that carries out a response.
An intracellular receptor activates phospholipase C, which cleaves a membrane protein to form IP
, which then activates the opening of an ER channel protein, which releases cyclic AMP into the cytoplasm, where it binds to an intracellular enzyme that carries out a response.
This is a logical sequence.
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